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PrivacyPurdue University - 2022 Football Season
 | Purdue University Purdue Boilermakers 1031 Hovde Hall  West Lafayette, Indiana, 47907-1031 Phone: School Website: www.purdue.edu Football Stadium: Ross Ade Stadium Stadium Capacity: 62,500 Sports Website: www.purduesports.com |
Purdue University - 2022 Football Season
| Team | Score | Location | Opposition | Score | Result |
| Purdue | 31 | @ | Penn State | 35 | L |
| Purdue | 56 | Indiana State | 0 | W | |
| Purdue | 29 | Syracuse | 32 | L | |
| Purdue | 28 | Florida Atlantic | 26 | W | |
| Purdue | 20 | @ | (21) Minnesota | 10 | W |
| Purdue | 31 | @ | Maryland | 29 | W |
| Purdue | 43 | Nebraska | 37 | W | |
| Purdue | 24 | Wisconsin | 35 | L | |
| Purdue | 3 | @ | Iowa | 24 | L |
| Purdue | 31 | @ | (21) Illinois | 24 | W |
| Purdue | 17 | Northwestern | 9 | W | |
| Purdue | 30 | @ | Indiana | 16 | W |
| Purdue | 22 | N | (2) Michigan | 43 | L |
| Purdue | 7 | N | (16) Louisiana State | 63 | L |